Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: a clinical and histopathological evaluation.
Identifieur interne : 000100 ( Main/Exploration ); précédent : 000099; suivant : 000101Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: a clinical and histopathological evaluation.
Auteurs : F. Inchingolo [Italie, Grèce] ; S. Cantore [Italie, Grèce] ; G. Dipalma [Italie, Grèce] ; I. Georgakopoulos [Grèce] ; M. Almasri [Royaume-Uni] ; E. Gheno [Grèce] ; A. Motta [Italie] ; M. Marrelli [Italie] ; D. Farronato [Italie] ; A. Ballini [Grèce, Italie] ; A. Marzullo [Italie]Source :
- Journal of biological regulators and homeostatic agents [ 0393-974X ]
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Femelle (MeSH), Fibrine riche en plaquettes (MeSH), Humains (MeSH), Mâle (MeSH), Ostéonécrose de la mâchoire associée aux biphosphonates (anatomopathologie), Ostéonécrose de la mâchoire associée aux biphosphonates (métabolisme), Ostéonécrose de la mâchoire associée aux biphosphonates (physiopathologie), Ostéonécrose de la mâchoire associée aux biphosphonates (thérapie), Sujet âgé (MeSH).
- MESH :
- anatomopathologie : Ostéonécrose de la mâchoire associée aux biphosphonates.
- métabolisme : Ostéonécrose de la mâchoire associée aux biphosphonates.
- physiopathologie : Ostéonécrose de la mâchoire associée aux biphosphonates.
- thérapie : Ostéonécrose de la mâchoire associée aux biphosphonates.
- Adulte d'âge moyen, Femelle, Fibrine riche en plaquettes, Humains, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Aged (MeSH), Bisphosphonate-Associated Osteonecrosis of the Jaw (metabolism), Bisphosphonate-Associated Osteonecrosis of the Jaw (pathology), Bisphosphonate-Associated Osteonecrosis of the Jaw (physiopathology), Bisphosphonate-Associated Osteonecrosis of the Jaw (therapy), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Platelet-Rich Fibrin (MeSH).
- MESH :
- metabolism : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- pathology : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- physiopathology : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- therapy : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- Aged, Female, Humans, Male, Middle Aged, Platelet-Rich Fibrin.
Abstract
Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies. The aim of the present study was to assess the outcome of using platelet-rich fibrin (PRF) for the treatment of MRONJ in a single study group. Twenty-three consecutive patients (15 females and 8 males; aged 52-73 years) with MRONJ were enrolled in this study. These patients presented a history of bisphosphonate medication of varying duration, presence of exposed bone in the maxillofacial region for more than eight weeks, and no history of radiation therapy to the jaws. These patients were managed by surgical curettage and application of platelet rich fibrin (PRF). The outcomes were assessed using clinical and histopathological methods. On the basis of the present findings, we can conclude that PRF can act as an effective barrier membrane between the alveolar bone and the oral cavity and may offer a fast, easy and effective alternative method for the closure of bone exposure in MRONJ patients.
PubMed: 28958140
Affiliations:
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Inchingolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>City Unity College, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>City Unity College, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>World Academy of Growth Factors and Stem Cells in Dentistry, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Cantore, S" sort="Cantore, S" uniqKey="Cantore S" first="S" last="Cantore">S. Cantore</name><affiliation wicri:level="1"><nlm:affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>City Unity College, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>City Unity College, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Dipalma, G" sort="Dipalma, G" uniqKey="Dipalma G" first="G" last="Dipalma">G. Dipalma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>City Unity College, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>City Unity College, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Georgakopoulos, I" sort="Georgakopoulos, I" uniqKey="Georgakopoulos I" first="I" last="Georgakopoulos">I. Georgakopoulos</name><affiliation wicri:level="3"><nlm:affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>World Academy of Growth Factors and Stem Cells in Dentistry, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Dentist Education Institute, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Dentist Education Institute, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Almasri, M" sort="Almasri, M" uniqKey="Almasri M" first="M" last="Almasri">M. Almasri</name><affiliation wicri:level="3"><nlm:affiliation>BPP School of Health, University Faculty of Dentistry, Birmingham, UK</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>BPP School of Health, University Faculty of Dentistry, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Gheno, E" sort="Gheno, E" uniqKey="Gheno E" first="E" last="Gheno">E. Gheno</name><affiliation wicri:level="3"><nlm:affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>World Academy of Growth Factors and Stem Cells in Dentistry, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Motta, A" sort="Motta, A" uniqKey="Motta A" first="A" last="Motta">A. Motta</name><affiliation wicri:level="1"><nlm:affiliation>Private practice, Trento, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Private practice, Trento</wicri:regionArea><wicri:noRegion>Trento</wicri:noRegion></affiliation></author><author><name sortKey="Marrelli, M" sort="Marrelli, M" uniqKey="Marrelli M" first="M" last="Marrelli">M. Marrelli</name><affiliation wicri:level="1"><nlm:affiliation>Maxillofacial Unit, Calabrodental Clinic, Crotone, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Maxillofacial Unit, Calabrodental Clinic, Crotone</wicri:regionArea><wicri:noRegion>Crotone</wicri:noRegion></affiliation></author><author><name sortKey="Farronato, D" sort="Farronato, D" uniqKey="Farronato D" first="D" last="Farronato">D. Farronato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Morphologic and Surgical Sciences, Insubria University, Varese, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphologic and Surgical Sciences, Insubria University, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Ballini, A" sort="Ballini, A" uniqKey="Ballini A" first="A" last="Ballini">A. Ballini</name><affiliation wicri:level="3"><nlm:affiliation>City Unity College, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>City Unity College, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>World Academy of Growth Factors and Stem Cells in Dentistry, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Marzullo, A" sort="Marzullo, A" uniqKey="Marzullo A" first="A" last="Marzullo">A. Marzullo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Emergency and Organ Transplantation, Section of Pathological Anatomy University of Bari Aldo Moro, Bari, Italy</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Emergency and Organ Transplantation, Section of Pathological Anatomy University of Bari Aldo Moro, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of biological regulators and homeostatic agents</title><idno type="ISSN">0393-974X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Bisphosphonate-Associated Osteonecrosis of the Jaw (metabolism)</term><term>Bisphosphonate-Associated Osteonecrosis of the Jaw (pathology)</term><term>Bisphosphonate-Associated Osteonecrosis of the Jaw (physiopathology)</term><term>Bisphosphonate-Associated Osteonecrosis of the Jaw (therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Platelet-Rich Fibrin (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Femelle (MeSH)</term><term>Fibrine riche en plaquettes (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Ostéonécrose de la mâchoire associée aux biphosphonates (anatomopathologie)</term><term>Ostéonécrose de la mâchoire associée aux biphosphonates (métabolisme)</term><term>Ostéonécrose de la mâchoire associée aux biphosphonates (physiopathologie)</term><term>Ostéonécrose de la mâchoire associée aux biphosphonates (thérapie)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Ostéonécrose de la mâchoire associée aux biphosphonates</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bisphosphonate-Associated Osteonecrosis of the Jaw</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ostéonécrose de la mâchoire associée aux biphosphonates</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bisphosphonate-Associated Osteonecrosis of the Jaw</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Ostéonécrose de la mâchoire associée aux biphosphonates</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Bisphosphonate-Associated Osteonecrosis of the Jaw</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Bisphosphonate-Associated Osteonecrosis of the Jaw</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Ostéonécrose de la mâchoire associée aux biphosphonates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Platelet-Rich Fibrin</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Fibrine riche en plaquettes</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies. The aim of the present study was to assess the outcome of using platelet-rich fibrin (PRF) for the treatment of MRONJ in a single study group. Twenty-three consecutive patients (15 females and 8 males; aged 52-73 years) with MRONJ were enrolled in this study. These patients presented a history of bisphosphonate medication of varying duration, presence of exposed bone in the maxillofacial region for more than eight weeks, and no history of radiation therapy to the jaws. These patients were managed by surgical curettage and application of platelet rich fibrin (PRF). The outcomes were assessed using clinical and histopathological methods. On the basis of the present findings, we can conclude that PRF can act as an effective barrier membrane between the alveolar bone and the oral cavity and may offer a fast, easy and effective alternative method for the closure of bone exposure in MRONJ patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28958140</PMID><DateCompleted><Year>2017</Year><Month>12</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>12</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0393-974X</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>3</Issue><PubDate><MedlineDate>2017 Jul-Sep</MedlineDate></PubDate></JournalIssue><Title>Journal of biological regulators and homeostatic agents</Title><ISOAbbreviation>J Biol Regul Homeost Agents</ISOAbbreviation></Journal><ArticleTitle>Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: a clinical and histopathological evaluation.</ArticleTitle><Pagination><MedlinePgn>811-816</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">38</ELocationID><Abstract><AbstractText>Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies. The aim of the present study was to assess the outcome of using platelet-rich fibrin (PRF) for the treatment of MRONJ in a single study group. Twenty-three consecutive patients (15 females and 8 males; aged 52-73 years) with MRONJ were enrolled in this study. These patients presented a history of bisphosphonate medication of varying duration, presence of exposed bone in the maxillofacial region for more than eight weeks, and no history of radiation therapy to the jaws. These patients were managed by surgical curettage and application of platelet rich fibrin (PRF). The outcomes were assessed using clinical and histopathological methods. On the basis of the present findings, we can conclude that PRF can act as an effective barrier membrane between the alveolar bone and the oral cavity and may offer a fast, easy and effective alternative method for the closure of bone exposure in MRONJ patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Inchingolo</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>City Unity College, Athens, Greece</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cantore</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>City Unity College, Athens, Greece</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Dipalma</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>City Unity College, Athens, Greece</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Georgakopoulos</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Dentist Education Institute, Athens, Greece</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almasri</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>BPP School of Health, University Faculty of Dentistry, Birmingham, UK</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gheno</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Motta</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Private practice, Trento, Italy</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marrelli</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Maxillofacial Unit, Calabrodental Clinic, Crotone, Italy</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farronato</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Morphologic and Surgical Sciences, Insubria University, Varese, Italy</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ballini</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>City Unity College, Athens, Greece</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Marzullo</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Emergency and Organ Transplantation, Section of Pathological Anatomy University of Bari Aldo Moro, Bari, Italy</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>J Biol Regul Homeost Agents</MedlineTA><NlmUniqueID>8809253</NlmUniqueID><ISSNLinking>0393-974X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059266" MajorTopicYN="N">Bisphosphonate-Associated Osteonecrosis of the Jaw</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073183" MajorTopicYN="Y">Platelet-Rich Fibrin</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28958140</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Midlands de l'Ouest</li></region><settlement><li>Athènes</li><li>Birmingham</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Inchingolo, F" sort="Inchingolo, F" uniqKey="Inchingolo F" first="F" last="Inchingolo">F. Inchingolo</name></noRegion><name sortKey="Ballini, A" sort="Ballini, A" uniqKey="Ballini A" first="A" last="Ballini">A. Ballini</name><name sortKey="Cantore, S" sort="Cantore, S" uniqKey="Cantore S" first="S" last="Cantore">S. Cantore</name><name sortKey="Dipalma, G" sort="Dipalma, G" uniqKey="Dipalma G" first="G" last="Dipalma">G. Dipalma</name><name sortKey="Farronato, D" sort="Farronato, D" uniqKey="Farronato D" first="D" last="Farronato">D. Farronato</name><name sortKey="Marrelli, M" sort="Marrelli, M" uniqKey="Marrelli M" first="M" last="Marrelli">M. Marrelli</name><name sortKey="Marzullo, A" sort="Marzullo, A" uniqKey="Marzullo A" first="A" last="Marzullo">A. Marzullo</name><name sortKey="Motta, A" sort="Motta, A" uniqKey="Motta A" first="A" last="Motta">A. Motta</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Inchingolo, F" sort="Inchingolo, F" uniqKey="Inchingolo F" first="F" last="Inchingolo">F. Inchingolo</name></region><name sortKey="Ballini, A" sort="Ballini, A" uniqKey="Ballini A" first="A" last="Ballini">A. Ballini</name><name sortKey="Ballini, A" sort="Ballini, A" uniqKey="Ballini A" first="A" last="Ballini">A. Ballini</name><name sortKey="Cantore, S" sort="Cantore, S" uniqKey="Cantore S" first="S" last="Cantore">S. Cantore</name><name sortKey="Dipalma, G" sort="Dipalma, G" uniqKey="Dipalma G" first="G" last="Dipalma">G. Dipalma</name><name sortKey="Georgakopoulos, I" sort="Georgakopoulos, I" uniqKey="Georgakopoulos I" first="I" last="Georgakopoulos">I. Georgakopoulos</name><name sortKey="Georgakopoulos, I" sort="Georgakopoulos, I" uniqKey="Georgakopoulos I" first="I" last="Georgakopoulos">I. Georgakopoulos</name><name sortKey="Gheno, E" sort="Gheno, E" uniqKey="Gheno E" first="E" last="Gheno">E. Gheno</name><name sortKey="Inchingolo, F" sort="Inchingolo, F" uniqKey="Inchingolo F" first="F" last="Inchingolo">F. Inchingolo</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Almasri, M" sort="Almasri, M" uniqKey="Almasri M" first="M" last="Almasri">M. Almasri</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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